Top Testosterone Supplements That Work More Than 4,000 years

Testosterone supplements have their own formula to boost their health claims. 

The best testosterone supplements contain core natural ingredients such as Tongkat Ali, Ashwagandha, Maca or Panax Ginseng; some of which is used for more than 4,000 years.

So, which is the best testosterone supplement for men in the 21st century?

Should you pick single-ingredient testosterone supplements, or multi-herbal testosterone boosters that contains black-pepper, caffeine, garlic or even D-aspartic acid?

In this article, you will find valuable insights into the top best testosterone supplements for men’s health that deliver superior and consistent results.

You will also learn about key ingredients that are used in testosterone boosters, and which are the most effective testosterone supplement that work for men’s health.

Lets find out more!

Do you need testosterone supplements?

Testosterone supplements are used by mostly men when they experience low-testosterone symptoms and testosterone deficiencies due to age or lifestyle.

Most men consume testosterone supplements to keep them revitalized at all times, and to avoid premature aging symptoms.

Natural testosterone supplements are more effective than Testosterone Replacement Therapy (TRT) in many ways. Many reported side effects and gained more weight after TRT treatment.

Testosterone supplements are suitable to be taken daily at the right doses. You may consume if you exhibit low testosterone symptoms such as:

  • Low sex drive
  • Erectile dysfunction
  • Low stamina
  • Decreased in energy
  • Mild stress, depression or lack of focus

"When testosterone drop below the lower limit, they can start experiencing symptoms like diminished sex drive, erectile dysfunction, subfertility, low stamina, muscle atrophy, decreased energy and lower mood."

Dr. Luke Pratsides, lead GP at Numan.

There are 12 warning signs of low testosterone for men which you need to be aware of before choosing testosterone supplements as your best option.

And if you think Testosterone Replacement Therapy (TRT) is better, then please read more about the pros and cons of TRT vs. Testosterone Boosters.

Key ingredients behind testosterone supplements

Core Ingredients

Active ingredients found in most testosterone supplements.

  • Tongkat Ali
  • Ashwagandha
  • Panax Ginseng
  • Fadogia Agrestis
  • Horny Goat Weed
  • Tribulus Terrestris
Non-Core Ingredients

Supporting ingredients are mixed with core ingredients to enhance absorption of bioactive ingredients or to produce testosterone-like effects.

  • Green Tea
  • Vitamin D
  • D-Aspartic acid
  • Fenugreek
  • Pomegranate
  • Zinc
  • Vitamin B6
  • Black pepper
  • Garlic extract
  • Vitamin B5
  • Magnesium
  • Melatonin
  • Maca
  • Horny Goat Weed
  • Calcium
  • Boron
  • Bioprene

Not all ingredients or herbs are proven to boost testosterone. Some lack clinical tests or scientific evidence.

As with most testosterone supplements, adding 1 or more ingredients may not give you 2x more effects on testosterone.

So, 1+1 is NOT equal to two.

You will find out more shocking evidence in this article.

The fad behind using multi-herbal formulation as a T-booster was driven by a flawed theory that each herb has its own function to boost testosterone and will deliver a compounded effect when mixed together. For example:

  • Enhancing the release of testosterone from LH, or from adrenal glands
  • Accelerating the absorption of nutrients in the body
  • Activating other hormones that is responsible to produce testosterone in other parts of the body.

Does Testosterone Supplement Work?

Testosterone supplements produce mixed results, and it is largely dependent on its ingredients and formulation.

So, don’t expect testosterone to work on everyone.

The reality is, most testosterone supplements for men with mixed formulations are not clinically tested on humans.

In the best-case scenario, the compounded testosterone effect from testosterone supplements is mainly driven by core active ingredients (eg: Tongkat Ali, Panax Ginseng, etc).

Now, here is the hard truth.

Only 24.8% of T-boosters in the US had data to support its claims

Institute of Urology, The University of Southern California (2019)

Let’s investigate which ingredients are proven to boost testosterone later in this article.

Proven ingredients to boost testosterone

There are only a few ingredients, i.e vitamins or herbs, that are clinically proven to boost testosterone. Some ingredients are backed by sufficient scientific evidence, research or clinical tests.

A research study on the top 50 testosterone supplements (T-booster) by the Institute of Urology from the University of Southern California was shocking.

With only 24.8% of T-boosters having data to back their claims, researchers found that only a few ingredients have sufficient scientific evidence to prove the effect of boosting testosterone.

Here is the summary of the research findings.

T-Booster Ingredients

Does it increase testosterone?

Tongkat Ali


Panax Ginseng


Horny Goat Weed




D-Aspartic Acid

Tribulus Terrestris

Black pepper


Vitamin B5

Green Tea

Vitamin D

Vitamin B6








Gingko Biloba


Source: Testosterone Boosting Supplements Composition and Claims Are not Supported by the Academic Literature, Chase G et. al. (The World Journal of Men’s Health, Jan 2019)


✅✅✅✅✅ Substantial evidence with significant results

✅✅✅✅ Sufficient evidence with moderate results

✅✅ Moderate evidence with mixed results

✅ Lack of evidence with mixed results

❌ No evidence and it may not work

Tongkat Ali, Ashwagandha, Panax Ginseng are key active ingredients found in most of the top-selling testosterone supplements for men and have sufficient evidence to prove its effect on testosterone.

However, testosterone supplements that contain D-Aspartic Acid, Black Pepper, Tribulus Terrestris, Zinc, Magnesium or even Fadogia Agrestis that does NOT boost testosterone.


Drawing from the same research study from best 50 testosterone supplements sold in in the US, we found the following conclusion.

  • Approximately 70% of the T-boosters sold in the USA contains ingredients that are NOT backed by sufficient or conflicting scientific evidence – raising alarming questions on safety and efficacy.
  • Testosterone supplements such as TestPrime contain Tribulus Terrestis that have no effect on testosterone.
  • Fadogia Agrestis found in testosterone supplements contain insufficient research on the effect of testosterone.

To live on the hype of health claims by brand owners, most testosterone supplements for men retained its core ingredients in their formulation such as Tongkat Ali, Panax Ginseng – most of which are scientifically or clinically proven to increase testosterone.

"Tongkat Ali is the one and only active ingredient that is clinically proven and tested to improve testosterone and men’s health."

Dr. Ismail Tambi, Andrologist, Reproductive & Sexual Health

The Best Testosterone Supplements For Men

The best testosterone supplement brand for men is categorized into two types:

Best Proven Testosterone Supplement: Single Ingredient

Popular Testosterone Supplement: Multi-Ingredients

Comparing the best: Testosterone Supplements Review

Let’s look at some of the best and popular testosterone supplements in each category. Find out the best and most comprehensive testosterone supplement review in 2022.


AKARALI is the best natural testosterone supplement for men’s health in the US and UK due to its highly potent Tongkat Ali proprietary extract that boosts testosterone by up to 681%.

The MIT-formulated Physta® Tongkat Ali is clinically tested and backed by decades of research studies that show an increase in testosterone for men between 20 to 70 years old.

Most customer reviews on AKARALI reported positive results on testosterone effects such as libido and strength after 48 hours. Maximum peak benefit can be felt after four to twelve weeks.

If you are into single-ingredient formulations, AKARALI Tongkat Ali remains the best herbal supplement for men in 2022.

Key Ingredients (1 capsules per serving):
  • Tongkat Ali extract 200mg


  • Maximum testosterone increases between 40% up to 681%
  • Clinically tested to increase DHEA
  • Clinically tested on humans
  • Scientifically proven with 26 clinical tests
  • 12 proven health benefits.
  • Proprietary highly potent Tongkat Ali extract
  • Can be consumed in small doses
  • Suitable for both men and women
  • No side effects
  • 140 million doses produced and sold worldwide
  • Standardized extract protocol
  • Highly dependent on daily dosage to realize optimal gains.
  • Must be taken with regular exercises


TestoPrime is touted as the best testosterone boosting supplement on the market due to its formulation consisting of multi-natural ingredients. It is sold worldwide and popular amongst bodybuilders who crave for rapid results.

Its proprietary formulation consists high dose of active ingredients such as panax ginseng, green tea, d-aspartic acid, promegranate and garlic extract.

It may not be suitable for less active older men or general use, but commonly used by niche bodybuilders and sports amateurs who are seeking that boost from their exercises.

Key Ingredients (4 capsules per servings):
  • Green Tea Extract 4000mg
  • D-Aspartic acid 2000mg
  • Pomegranate Extract 4000mg
  • Panax Ginseng 8000mg
  • Garlic extract 1200mg
  • Vitamin D
  • Fenugreek 800mg
  • Zinc 40mg
  • Ashwagandha Extract 668mg
  • Vitamin B6 5.6mg
  • Black pepper extract
  • Vitamin B5 8mg
  • 90% of the ingredients are from natural herbs
  • Multi nutrients from multiple ingredients
  • Testosterone increase claim between 40 – 60%
  • Formulation not clinically tested on humans
  • Not clinically tested for efficacy
  • May cause jittery or insomnia
  • Must be consumed in high dosages (4 capsules for each serving) to realize health gains
  • Non-standardized extract

Prime Male

Prime Male is another popular testosterone supplement in the UK and the US, which are actively promoted by affiliates. It contains multi-ingredients which are less natural than testo-prime.

The proprietary mix-ingredient extract has been touted as the best testosterone supplement from men, extremely well thought.

However, many customers reported the side effects of diarrhea as reported in customer reviews.

Key Ingredients:
  • Vitamin D3 (as Cholecalciferol)
  • Vitamin K2
  • Vitamin B6
  • Magnesium
  • Zinc
  • D-Aspartic Acid
  • Panax Ginseng
  • Luteolin
  • Ashwagandha
  • Nettle Root
  • Black Pepper Extract
  • Boron
  • May suppress estrogen levels by preventing its conversion from testosterone
  • High dose of ashwagandha may cause sleepiness or increase the effects of sedatives.
  • D-Aspartic does not increase testosterone
  • Individual ingredient does not have sufficient evidence
  • Overall formulation is not clinically tested
  • Cause diarreha

Are Testosterone Supplements Safe?

Testosterone boosters with mix-herbal ingredients may cause abdominal pain, diarrhea, kidney failure and other health risks. Most mixed ingredients are not tested on efficacy and may cause liver and kidney complications.

A case study on a person consuming multi-ingredient testosterone supplements showed high levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indicating liver injury – as shown in the ultrasound scan images below.

Abdominal ultrasound images of liver, spleen, kidneys, aorta, pancreas, gallbladder, , prostate and urinary bladder after taking multi-ingredient testosterone supplements (Source: Effect of testosterone boosters on body functions, 2018)

Our top Pick: Best Natural Testosterone Supplements for Men’s Health

Single-ingredient Tongkat Ali supplement is the best and safest natural testosterone supplement for men. Multiple studies and clinical trials showed Tongkat Ali does increase testosterone across men between 20-70 years old.

Depending on the Tongkat Ali dosage, you may expect between increase of testosterone between 20% to 581% after consuming Tongkat Ali for 12 weeks.

Used by primal men 4,000 years ago, latest high-tech potent Tongkat Ali Physta® extract (using standardize hot water extract) delivers 10x more consistent results on testosterone.

Tongkat Ali’s hormonal benefits to men and positive effect to our endocrine system including the reproductive system is the best testosterone supplement for men below 50.

Tongkat Ali supplement is now more popular than Ginseng, Fadogia Agrestis or even Turkesterone due to its effect on testosterone, based on 300+ research studies and clinical trials.

Tongkat Ali is the best testosterone supplement due to its proven clinical tests on humans, backed by 20 years of research on testosterone, DHEA and DHT.

Ilan Joffee, President Core Supplements LLC (USA)

In addition, Tongkat Ali has sufficient clinical evidence over the last 20 years to prove its effect on boosting testosterone, free-testosterone and DHEA on both men and women.

However, those exceptional gains will only work if you consume 100% Tongkat Ali root or clinically tested Tongkat Ali products to reap the most benefit.

Please keep in mind to purchase the most potent Tongkat Ali in the market. This usually gives you a higher chance of boosting testosterone to meet your expectations.

Remember, not all herbal products are created equal.

Hence, why fine-quality Tongkat Ali extract gives you the most testosterone gains.

Parting Thoughts

The best testosterone supplement that will benefit men’s health must be backed decades of research studies.

Tongkat Ali, Panax Ginseng and Ashwagandha remained the popular T-booster supplement for men due to its decades of scientifically proven effects on libido and sperm motility, muscle strength, anaerobic performance in sports and mood.

In fact, it is the oldest herb that are used in most testosterone supplements known to man.

Taking a pure 100% single-ingredient supplement will do more justice in boosting your testosterone to gain those benefits rather than taking an unproven formulation.

Regardless of your health objectives, quality testosterone supplements for men such as the MIT-formulated natural testosterone booster are making a comeback on Amazon.

And you should seriously give it a try!

Naressa Khan contributes regularly on AKARALI. As a researcher and investigative journalist specializing in nutrition and natural wellness, Naressa is all about creating, deconstructing, and reassembling meaningful content through words and facts. With this approach always in mind, she eagerly explores the nuances in life via the aspects of lifestyle, culture, travel, health, and wellness in Malaysia .


The content published on this website is for educational purposes and should not be viewed, read, or seen as a prescription or constitute any form of medical advice. We recommend you consult your nearest GP or doctors before consuming Tongkat Ali or any products which contain Tongkat Ali. For further information, kindly refer to our Frequently Asked Questions (FAQ) for more information.

Share this post

Related Posts

7 Responses

  1. Great article! Excellent review about natural testosterone boosters. In my experience, the best testosterone supplement that I tried was the one containing Ginseng and Tongkat Ali. I understand you cannot combine those two herbs. But I tried two separate natural supplements within a span of 3 months. The Tongkat Ali performed way better after my blood test. The results showed increase of free testosterone after four solid weeks. I cannot remember the brand but it has standardized Tongkat Ali extract with 3% eurycomanone. I believe the amazing results were also attributed by my regular cardio. Well just maybe.

    1. Hi Jonathan, thanks for your comments. Yes, most consumers prefer using Tongkat Ali in various doses (between 100mg – 600mg) to restore, or to increase their testosterone levels. Most are men between 40-70 years. But please ensure you get the super-potent Tongkat Ali extract that is guaranteed to be the natural testosterone supplement that you ever need. The result from studies showed that testosterone levels can be boosted by 600% if you are taking multivitamins at the same time.

  2. How did TestoPrime can as one of the best testosterone booster? The product is crap and did not show any results. My testosterone was lower after consuming TestoPrime! Please avoid TestoPrime at all cost. It is not worth your money. Besides, the ingredients are formulated by a bunch of herbal junkies without any knowledge what it does to your health, kidney or other possible organ failure. We should educate people not to buy untested testosterone supplements and those fake T-boosters in the US. Spread the word!! Don’t spread hate. Spread love!

    1. Thanks for sharing your experience on various testosterone supplements. Not all T-boosters will work, and some are dangerous to health. We advice others to consult their respective doctors before consuming any testosterone supplements, T-boosters or even natural testosterone which are not clinically tested.

  3. The best testosterone supplement for men is Tongkat Ali. Period.

    Nothing beats this herb to be honest! I don’t understand why people think Fadogia Agrestis can do a better job in boosting testosterone. Are they blinded by whatever was said by Dr. Andrew Huberman on Joe Rogan’s podcast? Like seriously?? That dude is not even a scientist or expert in herbal formulation, research or even herbal extraction technologies!

    1. In our opinion, Fadogia Agrestis has less than 10 research studies in the last 30 years compared to Tongkat Ali (300+ research studies and clinical trials). But Fadgoia was heavily marketed with false claims by so-called experts in the USA. Fadogia has not reported effects on testosterone. There are very few T-booster supplements that are using Fadogia as one of the key active ingredients. The best testosterone supplements for men has Tongkat Ali or Panax Ginseng as their core active ingredients. Please avoid T-boosters which has Fadogia Agrestis in it, as it may not be tested against safety.

  4. It is interesting, or should i say I am thoroughly amused when reading the comments on this article. I can assure you one thing, the T-booster supplements in the US is just filled with junk products. So many health claims, but with so little results.

    WARNING TO READERS – Natural testosterone supplements can work positively for you if you find the right brand, or the right mix of ingredients. I tend to stick to single-ingredient supplement as my testosterone booster. Herbs like Tongkat Ali worked surprisingly well for my age (Iam 55). I will not argue about percentage increase of testosterone from my blood test, but the testosterone effects on my sexual desire, performance, erection and even general stamina is something to be proud of!

Leave a Reply

Your email address will not be published. Required fields are marked *