Tongkat Ali vs Fadogia Agrestis. Which is better and safer? Benefits, Combo & Drawbacks

Consumers are using scientific evidence to make better decisions when comparing Tongkat Ali vs. Fadogia Agrestis. And you should too.

Tongkat Ali and Fadogia Agrestis are androgenic plants with increasing claims of health benefits that include increasing testosterone, libido, muscle strength and are used widely as a sports performance enhancement supplement.

However, which is a better herb? And should you combine Tongkat Ali and Fadogia?

This article shares the benefits of Fadogia Agrestis and Tongkat Ali, its side effects, safety limits, toxicity levels and whether the Tongkat Ali Fadogia combo brings the best results.

Our guide will help you decide how to use Tongkat Ali and Fadogia effectively and which herb is better to achieve your health goals.


Originating from Nigeria, pairing Fadogia Agrestis with Tongkat Ali may seem like a perfect health stack. Celebrity doctor Dr. Andrew Huberman once told his audience in 2022 how Fadogia and Tongkat Ali may be used to boost testosterone. His statement caught many nutritionists, botanists and scientists by surprise.

Further investigations revealed that Fadogia Agrestis may be another overly-hyped herbal supplement without strong clinical evidence. For example, Turkesterone failed to attract interest from users due to the lack of scientific evidence, human studies and unknown severe side effects.

"Never fall for the Nigerian Fadogia scam.”

Eventually, some will hate us for exposing the truth.

With less than 10 research studies since 1970, there is a lack of scientific evidence and clinical tests on humans to prove Fadogia’s health benefits. In comparison, Tongkat Ali recorded more than 300+ studies and human clinical tests in the last 20 years.

Yes, you may combine Tongkat Ali and Fadogia Agrestis to gain added benefits such as energy, strength and  testosterone boost too. Although much of these compounded effects are fueled by the powerful bioactive ingredients of Tongkat Ali.

Now, let’s find out which herb is better to achieve various health goals.


Fadogia Agrestis

✅ 10 research studies 

✅ May boost testosterone

✅ May boost muscle strength

❌ Not clinically tested on humans

❌ No impact on libido

❌ No impact on sperm motility 

❌ No impact on mood or stress

❌ No impact on the immune system

Tongkat Ali

✅ 300+ research studies and clinical trials 

✅ Clinically tested on humans since late 90s

✅ Proven to boost testosterone

✅ Proven to increase muscle strength

✅ Proven to increase anaerobic power  

✅ Proven to boost libido & desire

✅ Proven to increase sperm motility 

✅ Proven to reduce cortisol, stress & tension

✅ Proven to boost dopamine

✅ Proven to reduce uric acid

✅ Proven to boost the immune system

Summary: Tongkat Ali vs. Fadogia Agrestis

Testosterone Production

Multiple RCT studies and meta-analyses showed Tongkat Ali produces more total testosterone by reducing SHBG compared to Fadogia. Fadogia’s effect on testosterone is limited to animal studies. However, combining both Tongkat Ali and Fadogia may result in a substantial increase in total testosterone based on anecdotal evidence shown from the user’s bloodwork after a few weeks.


Weight Loss

Tongkat Ali works better as a weight loss supplement compared to Fadogia Agrestis as it promotes faster body metabolism and reduction of body fat. Tongkat Ali’s studies showed a reduction in body fat loss and Body Mass Index (BMI) in obese adults after 100 days. On the other hand, there are no studies on the effects of fat loss or BMI in humans from taking Fadogia Agrestis.


Mood & Stress

Tongkat Ali performs better in reducing stress and improving mood caused by hormonal imbalance compared to Fadogia Agrestis. Various studies that showed Tongkat Ali is able to reduce cortisol (i.e stress hormones), boost dopamine (happy hormone) and improve overall mood profile (Tension, Anger, Confusion and Stress reduction). Tongkat Ali is also widely used to reduce brain fog to gain better mental clarity in the morning compared to Fadogia.


Immune System

Tongkat Ali may be a better choice to boost your immune system compared to Fadogia Agrestis due to anti-oxidant and anti-bacterial properties. Randomized controlled Tongkat Ali clinical trial on humans showed improvement of the immune system after 12 weeks, with an increase of CD4+, T-cells. No study was done on Fadogia Agrestis to investigate the effects on the immune system at this juncture. Fadogia recorded no anecdotal evidence in boosting immune system.


Sports Performance

Both Tongkat Ali and Fadogia Agrestis recorded substantial improvements in stamina, muscle strength and energy. However, Tongkat Ali is more widely used and trusted as a sports supplement for pre-workouts and post-workout muscle recovery compared to Fadogia. Combining Tongkat Ali and Fadogia may improve muscle strength and growth based on anecdotal evidence by users in the fitness community.



Tongkat Ali performs better than Fadgoia in boosting libido and men’s fertility. Studies on Tongkat Ali showed longer erection time and higher sperm count and motility in men with androgen deficiencies (i.e low-T). Tongkat Ali delivers the same libido boost in young adult men compared to Fadogia Agrestis. Combining Tongkat Ali and Fadogia may increase libido due to the aftereffects of testosterone production.


Tongkat Ali vs. Fadogia Agrestis : Which is more popular?

Tongkat Ali is time-tested to be more popular than Fadogia Agrestis. Google data showed that consumer search interest in Tongkat Ali jumped exponentially by more than 50%, surpassing Fadogia Agrestis in Q2 to Q3 in 2022.

Our analysis revealed that the lack of user interest in Fadogia Agrestis is due to safety concerns and insufficient evidence to back its health claims.

Source : Google Trend Explorer Analysis on Tongkat Ali vs. Fadogia Agrestis from 2021-2022

Meanwhile, Tongkat Ali is more popular than Fadogia Agrestis due to its decades of clinical tests on humans, with rapid studies being conducted globally by independent research labs by medical professionals.

In comparison, Fadogia recorded less than 10 studies and limited to tests conducted on albino rats.

"Products should not be promoted as if they have benefits for our health when it’s never been proven that they work in humans.”

Despite the lack of scientific evidence, Fadogia and Tongkat Ali are both used by the fitness community, bodybuilders and sports amateurs with bold claims that it will boost testosterone, muscle growth and even libido.

The Fadogia Agrestis Tongkat Ali mix

The best Fadogia Agrestis Tongkat Ali brands out there each have their own unique formulation, typically ranging from 400mg-7,000mg of Fadogia that is added with 100mg to 400mg of Tongkat Ali extract into a single capsule.

The hype behind most Fadogia + Tongkat Ali supplements is to deploy a trick of adding a small quantity of Tongkat Ali with Fadogia in a single capsule to boost its overall health benefits, with claims that it may boost testosterone, libido and muscle growth).

According to Dr. Andrew Huberman from Huberman Lab, the best Tongkat Ali Fadogia Agrestis supplement contains a mix of ingredients in the following ratio:

  • Fadogia Agrestis: 600mg
  • Tongkat Ali: 400 mg

Fadogia Agrestis Supplement Review

The best-selling Fadogia Agrestis supplements in the US, UK and Australia that you should watch out for contain high concentration of Fadogia root extract, often at high dose of 600mg to 7,000mg per capsule. Although a high dose of 600mg Fadogia Agrestis signify higher potency that may lead to potential benefit such as libido or sperm count, this may be toxic to your kidneys and liver if taken long term, or more than 30 days.

Whilst user may opt to buy these hot selling Fadogia supplements, some brands contain high concentrate of Fadogia extract that is mixed with Tongkat Ali, Shilajit, Black Pepper and other ingredients which may expose higher risks on the liver and kidneys. A study published in 2023 in the Scientific African journal showed that Fadogia extract may lead to irreparable chronic kidney disease (CKD) and liver necrosis.

In addition, users are also cautioned against buying non-standardized (generic) Fadogia extract that may contain impurities or mixed with other deadly Fadogia species (eg: Fadogia cienkowskii), that are not detectable by most independent lab tests.

Review: Best-selling Fadogia Agrestis Supplement in USA

Most best-selling Fadogia Agrestis supplements in the US such as Momentous, ELMNT, Vinatura, Doublewood contain 400mg to 600mg of Fadogia extract in a single capsule. As most of the Fadogia Agrestis extract is sourced from the same supplier in the US, there is no distinct differences in terms of price, formulation or other attributes that are valuable to consumers.

It is worth noting that 600mg of Fadogia Agrestis may not be safe for liver or kidneys, as an animal study showed that inflammation of the kidneys and death of liver tissue can occur at 50mg /kg of bodyweight, which translate to Human Equivalent Dose (HED) of approximately 600mg based on an adult weight of 70kg.

Fadogia Agrestis Supplement Brands USA

Fadogia extract dosage

per capsule

Price (USD)


Momentous Fadogia Agretis




ELMNT 228,000mg Fadogia Agrestis Tongkat Ali




Vinatura Tongkat Ali & Fadogia Agrestis




DoubleWood Fadogia Agrestis 600mg




Dorado Nutrition Fadogia Agrestis 600mg Extract



Review: Best-selling Fadogia Agrestis Supplement in Australia

Fadogia Agrestis supplements such as Satoomi, Bebefen, Momentous are brands sold in Australia that boast high dose of Fadogia extract (400mg to 7,000mg per capsule) warrant further review of its side effects given the recent toxicity and negative safety impact on liver and kidneys. The risks of taking Fadogia Agrestis Tongkat Ali supplement (with polyherbal formulation extract) for testosterone or libido are similar despite Tongkat Ali’s nephroprotective effect on the kidneys.

It is worth noting that the efficacy, benefits and safety of Satoomi and Bebefen Fadogia have not been tested by FDA or independent clinical trials which raise concerns amongst functional health coaches and sports amateurs in Australia.


Fadogia Agrestis Supplement Brands Australia


Fadogia extract dosage

per capsule

Price (AUS)


Satoomi Fadogia Agrestis & Immune Support Supplement




Bebefen Fadogia Agrestis Capsules 9,300mg



22,100mg Fadogia & Immune Support Supplement




Benefits: Fadogia Agrestis + Tongkat Ali

Anecdotal user reviews reported faster muscle growth, and increased libido including stamina after combining Fadogia Agrestis and Tongkat Ali. However, the health benefits of combining Fadogia and Tongkat Ali are sketchy and not backed by science. There are currently no human clinical studies to support the benefits of Tongkat Ali and Fadogia Agrestis in a polyherbal formulation.

Some people claim that Fadogia agrestis can increase testosterone levels, which could help with sexual performance and athletic performance. But this claim isn't supported by research.

Those taking Momentous, Satoomi or Bebefen Fadogia Agrestis supplement may experience a boost of testosterone levels but these effects are driven by the addition of testosterone-boosting ingredients from Tongkat Ali (mostly found in doses of 100mg to 200mg per serving).

Other health benefits of the Fadogia-Tongkat Ali supplement combo are fueled by Tongkat Ali’s stronger bioactive ingredients such as eurycomanone, glycosaponin and which are clinically tested to increase testosterone and libido.

In fact, there are more risks of liver toxicity and kidney damage from high doses of Fadogia Agrestis extract at 400mg or 600mg found in most Fadogia and Fadogia-Tongkat Ali supplements. This is backed by the latest study in 2023 showing death of liver tissues and inflammation of the kidneys.

On that note, you probably gain more measurable and noticeable health benefits from consuming a potent single-ingredient Tongkat Ali supplement containing pure root extract powder that is clinically tested.

Demystifying the health benefits

Let’s deep-dive into the claimed health benefits of Tongkat Ali Fadogia supplements.

Here is an example.

600mg of Fadogia Agrestis + 400mg of Tongkat Ali (i.e 1,000mg of Fadogia Agrestis Tongkat Ali mix) may bring similar effects on testosterone or libido compared to 200mg of Tongkat Ali.

When formulating or marketing a herbal formulation, the total net gain from combining two (or more) herbs is NOT equal to the sum of the individual gains.

Yet, most people think 1 + 1 = 2 

Or, in this example; Testosterone Gain From Fadogia + Testosterone Gain From Tongkat Ali = 2

This allows further manipulation into thinking that the sum of 0.6 + 1.4 = 2

This is how we are wired to think when rationalizing the compounded effect of Fadogia Agrestis (at say 1,400mg) and Tongkat Ali (at say 600mg).

Unless it is clinically tested, combining Fadogia Agrestis and Tongkat Ali will NOT give you 2x higher testosterone gains, or 2x more libido, or the elusive 10x more muscle strength.

In fact, you can gain 2x higher testosterone gains or 2x more libido with a clinically tested potent Tongkat Ali at a lower dosage. 

Now, let’s find out more facts about Tongkat Ali and Fadogia Agrestis.

🔎 Key Facts: Fadogia Agrestis
  1. The total research study on Fadogia Agrestis is less than 10, with the same 6 papers being cited and recycled in every article or blog entry.
  2. Fadogia Agrestis has not been clinically tested or lab-tested to be safe.
  3. There are no clinical studies or clinical tests on humans. Fadogia is only tested on rats.
  4. Most studies on Fadogia Agrestis have been based on tests on rats and animals.
  5. There is no study on Fadogia Agrestis and how it could benefit women’s health.
  6. There is only ONE Fadogia Agrestis study to investigate its efficacy on testosterone in rats. The same study was performed to investigate libido potential in male albino rats in 2005.
  7. There is no study to prove Fadogia Agrestis’s effect on DHEA, testosterone, free testosterone, estrogen and how it affects the endocrine system.
  8. There has been no recent development or new findings on Fadogia Agrestis on how it can benefit human’s health.
  9. Fadogia Agrestis did not receive much attention, coverage or even reviews by medical professionals or health experts to reaffirm its efficacy on human health.
  10. Fadogia Agrestis is being falsely marketed in the US with false claims by heavily paid social media influencers.

Current research on Fadogia Agrestis doesn’t show enough evidence that this plant can help with any medical condition

🔎 Key Facts: Tongkat Ali
  1. Tongkat Ali has recorded more than 300+ research studies between 1999 – 2021
  2. Tongkat Ali has been clinically tested on hundreds of humans (both men and women), with more clinical trials than other known herbs in the history of mankind.
  3. Tongkat Ali has sound scientific evidence on how it may benefit women’s health.
  4. Multiple studies on Tongkat Ali’s effect on testosterone with validated test results by qualified scientists and medical professionals.
  5. Tongkat Ali has been clinically tested to raise dehydroepiandrosterone (DHEA) based on 105 male test participants. DHEA is a precursor hormone that helps to produce testosterone.
  6. Tongkat Ali studies on libido and men’s fertility showed positive results on erection hardness, erection time, sperm motility and other parameters.
  7. Tongkat Ali has been reviewed extensively and continuously by medical experts, health professionals, nutritionists and researchers around the world.
  8. Tongkat Ali was dubbed the Tree That Cures Thousand Diseases when it was first discovered by MIT scientists in 2003 due to its unique medicinal properties from bioactive compounds eurycomanone and eurypeptides.

Does Fadogia Agrestis has any risks or side effects?

There are serious toxicity risks and side-effects on Fadogia Agrestis as reported by medical and dietary experts.

🔎  Fadogia Agrestis: Side Effects & Toxicity

Fadogia side effects and toxicity studies are limited to animal tests (mainly rats and rabbits). Results from various studies conducted in 2008, 2009 and 2012 showed the following side-effects of Fadogia:

  1. Causes death in rats when administered at high dosage
  2. Kidney damage at higher doses of Fadogia Agrestis
  3. Damage to the animal’s liver and spleen
  4. Damage to the vocal cords
  5. Swelling of nasal mucosa
  6. Decreased appetite
  7. Increased heart rate in rats and rabbits
  8. Anemia in rabbits
  9. Toxic to the testicles

Common Fadogia’s side effects from consumers:

  1. Kidney pains
  2. Liver complications
  3. Chronic Nausea
  4. Heart palpitations
  5. Vomitting
  6. Impair testicular functions.
🔎  Is Fadogia Agrestis Safe?

Based on nutritional and health experts’ views, Fadogia Agrestis is NOT safe when consumed in high doses.

There are limited clinical studies on humans and past studies showed an adverse effect on kidney and liver functions.

  1. It may cause a testicular increase when consumed in high doses, and this may cause cancer risks.
  2. A 2009 and 2023 study showed that Fadogia Agrestis has adverse effects on the kidney and liver functions of albino rats after 40 days.
  3. The level of clinical toxicity in Fodgia Agrestis has not been thoroughly tested and may cause kidney failure on humans if consumed in high doses.

Nutrition and food science expert Zach Allison advised viewers on the risks of taking Fadogia Agrestis in his recent video.

In his review of Fadogia, Zach exposed the truth behind Fadogia Agrestis and highlighted the risks of Fadogia using data-driven facts from studies and other references.

Until we have more data (to prove otherwise), the risks on Fadogia Agrestis should be taken seriously.

He also commented on the risk vs. reward for those taking Fadogia Agrestis.

If you are taking unproven and experimental supplement to increase testosterone, you have to take into account the risk-to-reward ratio.

Despite his unpopular opinion about Fadogia, it makes a lot sense to stay away from Fadogia Agrestis until there are more research studies or clinical trials / tests on humans.

🔎 Does Fadogia Agrestis benefit women?

There are no research studies or clinical tests on the benefits or effects of Fadogia Agrestis on women’s health. Female users taking Fadogia Tongkat Ali supplements may experience some benefits such as an energy boost and better lean muscle development due to the effects of Tongkat Ali’s eurypeptides, saponin and another bioactive compound rather than compared to Fadogia Agrestis.

Increasing studies on how Tongkat Ali benefits women’s health is the reason why Tongkat Ali is used as an active ingredient found in most Fadogia supplements today.

Which herb deliver more health benefits? Tongkat Ali or Fadogia Agrestis?

When consuming any Fadogia Agresits-Tongkat Ali supplements, it is Tongkat Ali who does all the hard work whilst Fadogia gets the credit.

Thanks to all the false marketing hype,  Fadogia Agrestis failed miserably to meet consumers’ expectations despite it claims to increase testosterone by 350%.

Joe Rogan and Dr. Andrew Huberman raved about Fadogia in past talk shows, but both did not elaborate on the scientific studies to back the potential health claims.

In fact, Fadogia Agrestis’s health benefits are seen as a pseudo-science that is not backed by any randomized clinical trials or studies on humans.

Fadogia Agrestis has no scientific evidence to support any use.

Medical professionals, nutritionists and scientists did not further comment on Fadogia’s health benefits due to  lack of scientific studies in the last 20 years.

Here is the painful truth behind Fadogia Agrestis.

  • Fadogia Agrestis does not work as effectively as Tongkat Ali due to the low androgenic effects in its ability to boost testosterone.  
  • Based on studies on rodents, the human equivalent dosage for Fadogia tends to be extremely high; eg: 1,000mg to 4,500 mg to produce a modest biological response (i.e efficacy) in our body.
  • Consuming Fadogia Agrestis at extremely high dosage may cause higher risks of toxicity.

The perceived health benefits (or boosted effects) may potentially be due to the fact that Fadogia Agrestis act as an enabler or “booster” when combined with Tongkat Ali’s bioactive ingredients. 

The added boost may come from high-protein bioactive ingredients (eg: saponin) which are available in both Fadogia and Tongkat Ali.

But as we explained earlier, the total gain from a multi-herbal supplement is NOT the sum of its individual parts (i.e 1 + 1 is not equal to 2).

As a single-ingredient supplement, a potent Tongkat Ali extract may be stronger than Fadogia-Tongkat Ali combo. It requires a modest 200mg of pure extract to deliver all its scientifically proven benefits.

On the other hand, you may need a higher amount of 600mg to 1,000mg of Fadogia Agrestis to supercharge all Tongkat Ali’s amazing benefits.

Hence why most Tongkat Ali Fadogia Agrestis supplements are formulated in high dosages – without even considering the medium and long-term negative side effects of consuming Fadogia in high doses.

Let’s take look at a popular Tongkat Ali Fadogia Agrestis supplement on Amazon. Each capsule contains 1,000 mg of Fadogia Agrestis and Tongkat Ali.

Here is the breakdown for each serving (capsule) from its Supplement Facts:

  • Fadogia Agrestis Powder : 600mg
  • Tongkat Ali Powder: 400mg

Tongkat Ali has 20 years of scientifically proven benefits than Fadogia Agrestis in areas such as testosterone, muscle strength and libido.

Given Fadogia does not have sufficient studies to claim its effect on testosterone, energy, libido and many others, is Tongkat Ali doing a perfect job to mask Fadogia’s deficiencies and weaknesses?

Consumers are warned against adding Fadogia to their daily health stack, and to take note of the potential red flags of Fadogia from Andrew Huberman’s podcast

Despite Tongkat Ali is known as a versatile herb that reacts positively with Fadogia, Turkesterone, and Ashwagandha,  adding two different herbal extracts in a single capsule may not be a good idea.

Fadogia Agrestis Tongkat Ali supplement reviews

Best selling Fadogia Tongkat Ali supplements such as Dorado Nutrition (1200mg), Momentous Fadogia Agrestis, aSquared Nutrition Fadogia Agrestis and Salbinet Fadogia Agrestis Tongkat Ali (2,400mg) use a high dosage of Fadogia extracts that may be harmful to liver and kidneys.

Health experts warned against consuming high dosages of Fadogia exceeding 600mg per day that may be toxic to liver tissues, causing necrosis even at low dosages according to the latest toxicology study in 2023.

For example, Dorado Nutrition Fadogia Agrestis Tongkat Ali supplement (i.e 600mg of Fadogia + 400mg Tongkat Ali) may be harmful and toxic to your liver as it contains high amount of Fadogia Agrestis that will likely cause death of liver tissues (i.e necrosis) and kidneys damage. The negative side effects on liver and kidney from taking 600mg Fadogia was reported in a recent 2023 cellular toxicity study published at the Scientific African journal.

Although earlier positive comments by Dr. Huberman on Fadogia Agrestis supplements were promising, the extent of the liver and kidney damage is deemed irreparable as shown in two studies (2009 and 2023). In short, long-term use of Fadogia Agrestis is not advisable in any current form or condition.

Behind Tongkat Ali Fadogia Supplement Boost

In theory, Fadogia Agrestis may act as an enabling agent when combined with Tongkat Ali as both contain adaptogenic properties that deliver synergistic effects on testosterone, libido or even muscle growth. This could be the reason why the Tongkat Ali Fadogia supplement is so popular despite the high risk of liver damage from Fadogia.

Single-ingredient from pure root potent Tongkat Ali is reported to deliver increased testosterone boosts between 50% to 500% when paired with other vitamins and thus the addition of Fadogia Agrestis may have compounded effects that are not well researched by scientists and health experts.

In fact, consuming a highly potent Tongkat Ali using standardized hot water extract as a standalone supplement may add more health benefits, giving users flexible options to adjust the required dosing and pairing it with other supplement stacks when required. 

This may explain why the Fadogia Tongkat Ali supplement may not be a safe option due to the high risk of exposure to liver and kidney damage from excessive dosing.

Single ingredient Tongkat Ali supplement vs Fadogia Agrestis Tongkat Ali combo supplement. Which is better?

Before we dive in, let’s rephrase that question for clarity.

Should you consume a herbal-mix combo supplement such as Tongkat Ali Fadogia Agrestis, or stick with a single-ingredient Tongkat Ali supplement?

Here is one perspective. And food for thought.

We have demonstrated that there are ZERO ADDITIONAL health benefits of adding Fadogia Agrestis with Tongkat Ali. 

To add on, Fadogia Agrestis has less than 10 research studies to back up its claims on testosterone, libido, muscle strength, and other health benefits. There are more negative downsides compared to the upsides of taking Fadogia.

As the herbal supplement industry is not regulated by FDA, brand owners are hyping up the placebo effects through paid personalities and influencers.

Joe Rogan & Dr. Andrew Huberman failed to convince consumers of the scientific evidence behind the benefits of Fadogia Agrestis.

The scariest part is that most health claims or benefits from Fadogia Agrestis are anecdotal and not backed by any clinical tests, or peer-reviewed research studies.

According to Jason from Core Supplements based in California, he said most best-selling Fadogia supplements on Amazon such as Momentous Fadogia have not been clinically tested to work on humans.

He added, “There are silent concerns amongst functional health coaches that have used Fadogia supplements on the liver damage that has not been widely publicized on social media in the US”.

All Fadogia Agrestis products on Amazon have NOT been clinically tested on humans

Yellow Tongkat Ali (Eurycoma Longifolia) is a more powerful androgenic plant than Fadogia Agrestis and its bioactive ingredients are scientifically proven to benefit male and female hormones.

FAQ : User Guide

Get more insights on how best to use Fadogia as a single supplement, or Tongkat Ali-Fadogia combo supplement. Find out the effectiveness and side effects on health.

Does Fadogia Agrestis supplement work?

Compared to Tongkat Ali which recorded 300+ studies to date, Fadogia Agrestis has limited studies to validate its efficacy,  effectiveness, and benefits to health. While anecdotal evidence from user experience suggests it may work to boost testosterone and libido, more research is required to reaffirm its pharmacological effects on hormones and other health benefits.

Does Fadogia Agrestis and Tongkat Ali boost testosterone?

According to health expert Dr. Kyle Gillet, “Tongkat helps with the conversion of multiple key steps where you synthesize testosterone,” whilst for Fadogia, “it will increase the release of luteinizing hormone from the pituitary gland”. Whilst these statements are taken from two separate studies, there are no combined studies to investigate the testosterone effects from combining Fadogia and Agrestis together.

Does Fadogia Tongkat Ali combo increase sperm count?

Studies on Fadogia and Tongkat Ali have both shown increase in sperm count. Whilst Tongkat Ali is reported to higher effect on sperm count based on human clinical studies, Fadogia’s effect of increasing sperm count comes with inherent negative side effects such as irreparable kidney damage and liver tissue degeneration (necrosis) at 50 mg/kg of body weight.

Does Fadogia Agrestis damage sperm cells or testes?

An animal study by Yakubu et al from the University of Ilorin Nigeria in 2007 showed that Fadogia Agrestis (18 mg/kg) caused “mild but reversible destruction” of spermatic cells and irreversible derangement on male testicular histology.

What is the recommended daily dosage for Fadogia?

Based on an animal study, Dr. Gillett said a safe dose of Fadogia is 300 mg per day, although aspiring bodybuilders and sports amateurs are taking a higher dosage of 600 mg three times a week depending on the body weight. Aspiring bodybuilders weighing 200 lbs are reported taking massive 700 mg to 1,450 mg of Fadogia which may have severe effects on health.

Does Fadogia affect liver or kidneys?

An animal study in 2023 concluded that Fadogia has adverse effects, causing irreparable damage to both the liver and kidneys. Rats exposed to 50 mg/kg of Fadogia extract showed ballooning necrosis (tissue degeneration and death) and massive inflammation in both the liver and kidneys.

Is Fadogia safe or toxic?

A recent study on albino rats showed that Fadogia is highly damaging to kidneys and liver at low dosages of 50 mg. In addition, the safety limit and toxicity of long-term use of Fadogia have not been established in any conditions, which suggests that Fadogia is potentially highly toxic to humans.

What are the side effects of Fadogia Agrestis?

The most severe side effects of Fadogia may cause irreparable kidney and liver damage if taken at higher dosage. Other common side effects include potential damage to vocal chord, increased blood pressure, increased heart rate, nausea, headaches and vomiting.

What is the best way to use Tongkat Ali and Fadogia?

If your health goals demand the use of both Tongkat Ali and Fadogia, the best way is to take both herbs in moderation at lower dosages for a short duration. A daily dosage 200 mg Tongkat Ali and 300 mg Fadogia is ideal for first-timers and those who experience fewer (or no side effects) may increase the dosage after 2 weeks or longer.

Parting Thoughts

Tongkat Ali outperforms Fadogia in terms of efficacy, safety and toxicity. You may use Fadogia Agrestis and Tongkat Ali as single-ingredient (separate) supplements based on your health goals to enable optimal dosing that is safe for short-term use. This enables you to reduce the risks of side effects and potentially mitigate the impact on liver and kidney damage.

Whilst the Tongkat Ali-Fadogia supplement can be used to enhance your sports performance and boost your testosterone faster, it is best to stick to single-ingredient standalone Tongkat Ali supplements (preferably made from pure standardized hot water extract) which are clinically tested to benefit your health.

As the harmful effects of Fadogia outweigh the health benefits, Fadogia Agrestis remains a high-risk sports-enhancing supplement that warrants further clinical tests and investigations to ensure its safety and efficacy.

We strongly recommend to consult your nearest doctor before consuming any Fadogia Agrestis Tongkat Ali supplements.

Naressa Khan contributes regularly on AKARALI. As a researcher and investigative journalist specializing in nutrition and natural wellness, Naressa is all about creating, deconstructing, and reassembling meaningful content through words and facts. With this approach always in mind, she eagerly explores the nuances in life via the aspects of lifestyle, culture, travel, health, and wellness in Malaysia .


The content published on this website is for educational purposes and should not be viewed, read, or seen as a prescription or constitute any form of medical advice. We recommend you consult your nearest GP or doctors before consuming Tongkat Ali or any products which contain Tongkat Ali. For further information, kindly refer to our Frequently Asked Questions (FAQ) for more information.

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12 Responses

  1. Valid points indeed. However, how did Dr. Andrew Huberman have the confidence to put it on the spotlight more than once? He’s very careful with what he says and it does strike me as odd that he would give something with “poor research” this status. Seems like something’s off.

    1. I believe he mentioned once that he prescribed Fadogia to military or profesionnal sports athletes, as a way to circumvene regulations about steroids. If you analyse this statement carefully, you will notice that professionnal sports have become a sort of race between the anti-doping doctors and the other doctors working with the athletes to help them win. The doctors working for the athletes have their own playbooks that are constantly in evolution to keep the athletes at least one notch ahead of the other athletes and ahead of the anti-doping tests. What we could understand is that fadogia is a page of the coaches’ playbook that has been around for long enough that it’s no longer top secret, and since it may help a lot of regular people and is easy to buy, Huberman just decided to disclose that secret. He was careful to recommend a lower dose than what other people recommend, as a protection against the risk of toxicity that is known about fadogia (but honestly, I believe that actual synthetic steroids come with a much longer list of side effects and health risks).

  2. Looking what Dr. Andrew Huberman said his interview with Joe Rogan, I reckon he is not equipped, nor has the knowledge to talk about Fadogia Agrestis. After reading this article, I don’t think he even know that Fadogia has very few studies to verify its health benefits.

    Something is off here. I doubt he is able to convince the public on the merits of Fadogia. Or is he just another snake oil seller? God knows. There are many “Doctors” with hidden agenda these days.

    TBH, I tried Fadogia (by DoubleWood supplement) in high doses for 4 weeks with no effect on testosterone or libido! I took a blood test to prove there wasn’t any increase in my free and total testosterone. The Amazon world is filled with fake claims by brand owners on Fadogia. Beware of Fadogia and stay from herbs that makes too much noise and hype on social media. Thats my two cents worth.

    1. The two cents are about what your shilling is worthy. Beside Rogan is a circus show for snake oils sales and Huberman has his routines in such venues, I think the author and the fake comments following are even worst, demostrating that people with agendas are unable to present any kind of information without giving away what they are really about.

  3. I disagree with you Joel. I am nutritionist for 15 years and one of my areas of expertise is herbs and traditional medicine. I can honestly tell you that those playbook for sports professionals are filled with BS. Why should you roll out untested herbs like Fadogia Agrestis to military, that has only 8 research studies? And to add, Fadogia Agrestis studies ARE DONE on RATS! Animal tests are just a preliminary tests. Fadogia Agrestis ARE NOT CLINICALLY TESTED ON HUMANS! This is bad for the liver, kidney and not may cause cancer. Huberman should not be discussing, advising or promoting Fadogia Agrestis to anyone if the herb is not thoroughly tested. He did not present the usage of Fadogia clearly to the public. I hate to say this, but until Fadogia has at least 100 research studies on humans, its efficacy and safety are not conclusive. And it SHOULD NOT BE PROMOTED OR SOLD AS herbal supplement. We are risking our lives here!

    1. A world wide mass forced use of genetic therapies without 100 published studies apart for those telling that they kill people and sterilize the rest, would give you a better understanding of how ridiculous your comment is. Science is a craft, often a craft of evil. Scientist are low hanging prostitutes that will statistically demonstrate just about anything for money. Those using $cience to avvalorate their interests are terrible people but those regurgitating that “science” deserve only to be ridiculized and be barred to speak.

  4. My experience is better with Tongkat Ali than Fadogia. For testosterone and energy booster, I will continue to use Tongkat Ali. It’s better to use tried and tested herb IMHO. Not sure what’s the fuss is all about with this combo-mix. I found single ingredient supplements work more effectively.

    1. Thanks for sharing your experience on Tongkat Ali vs. Fadogia Agrestis. We receive similar experiences from others. Fadogia is a popular herbal supplement for men and to enhance sports performance. However, most consumers in the US are not getting the whole truth about Fadogia Agrestis vs. Tongkat Ali. In fact, Tongkat Ali is the best testosterone supplement compared to Fadogia Agrestis. Our research showed that most of the best-selling T-boosters sold in the market today contains Tongkat Ali. Here is the link for more information about key ingredients that are used in testosterone supplements for men.

  5. I tried both, but Tongkat Ali performs way better than Fadogia Agrestis! For those who think Tongkat Ali is mild, and you could be wrong. The strongest and most potent Tongkat Ali are clinically tested. I can vouch from my 10 years of experience is that the best Tongkat Ali on Amazon is AKARALI brand – 100% clinically tested on humans and MORE POTENT than Fadogia. Here is the link

    1. Joe Rogan Fadogia Agrestis formulation is a scam and overly promoted. I don’t think the formulation is not tested on humans. The reason why Fadogia Agrestis is popular is because it is marketed by Dr. Andrew Huberman. I won’t buy any Fadogia (or any herbal supplements) that is marketed by “Doctors” in the USA. And I agree with you that Tongkat Ali doesn’t need doctor’s spokesperson to convince people to buy. With more than 300 studies, that what makes Tongkat Ali more authentic and real than Fadogia Agrestis.

  6. Iam 35 and Fadogia didn’t work on me. Here is my review of Fadogia. Did my blood test and found no increase in testosterone after consuming Fadogia for 5 weeks. My verdict of Tongkat Ali vs. Fadogia is simple. If you want a significant boost of health with increase in testosterone, then choose Tongkat Ali. Tongkat Ali seemed to work better than Fadogia Agrestis for people in the age group between 35 and 70 to boost testosterone. You guys should check out some great article here on how Tongkat Ali helps you to revitalize your health and work productivity.

  7. Fadogia Agrestis is not safe and it has inherent risks. Why are you guys still buying a risky herbal product that is not tested on humans? To top it up, Fadogia Agrestis has no significant health benefits. There are many who reported adverse side-effects from consuming Fadogia too. The problem with buying Fadogia Agrestis or Tongkat Ali in the US is that they dilute with impurities. And consumers end up enjoying placebo effects from Fadogia. Next time you buy, look out for the best Tongkat Ali from Malaysia!

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