Growing pre-clinical, clinical trials and research studies reaffirm Tongkat Ali’s benefits on health. Discover a wide range of Tongkat Ali clinical studies on humans.
There is a growing demand for consumers to switch to clinically-tested Tongkat Ali supplements as it works better (i.e higher efficacy and potency) and are safe.
Clinically tested Tongkat Ali supplements are at par with pharmaceutical-grade complementary medicines that meet quality standards.
This article provides a list of trusted Tongkat Ali clinical trials and studies, which are tested on both men and women.
Tongkat Ali studies conducted using placebo-controlled and randomized tests are the gold standard of any clinical trial. And this is used as a basis to provide any health claims used in Tongkat Ali supplements.
Our list of Tongkat Ali clinical trials and studies provides scientific evidence and empirical data to show that Tongkat Ali works to deliver its intended benefits.
Note:
The Tongkat Ali clinical studies and tests published in this article were conducted using Physta® Tongkat Ali hot water standardized extract.
A comparative study investigating the effects of Physta® Tongkat Ali (TA) extract on elderly individuals as an ergogenic supplement. 25 test subjects consisting of 13 physically active male and 12 physically active female seniors were supplemented with 400mg of Tongkat Ali extract daily for 5 weeks.
Conclusions:
The study confirmed the ergogenic benefit of Physta Tongkat Ali for physically active seniors and its potential to increase free testosterone and muscle strength. Physta Tongkat Ali supplement was found to have no adverse effects on senior recreational athletes.
A randomized, placebo-controlled, and parallel study investigating the effects of 50mg Physta® Tongkat Ali + multivitamins (MV) on quality of life, mood and stress on 93 men and women (25 – 65 years) for 24 weeks.
Conclusions:
This study found that participants who were moderately stressed and supplemented with Physta Tongkat Ali and multivitamins showed significant improvements in quality of life, mood, stress, vigour, mental component, emotional well-being, cognition, and testosterone levels over a 12-week period.
A randomized, double-blind, placebo-controlled study investigating the effects of 200mg Physta® Tongkat Ali (TA) extract for 4 weeks on 63 (32 men and 31 women) moderately stressed test subjects
Conclusions:
Overall, the study confirmed the benefit of Physta Tongkat Ali for men and women for lowering symptoms of stress while improving testosterone levels and lowering cortisol levels. The test subjects also showed an increase in libido levels.
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 200mg Physta® Tongkat Ali on the immune system of 84 men and women (40 – 59 years) for 4 weeks.
Conclusions:
Physta Tongkat Ali supplementation contributes to immunological improvement by stimulating the production of more T-cells, CD4+ cells, leading to a stronger immune system.
A placebo-controlled, double-blind, matched-paired study to assess the impact of TA supplementation on the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in healthy young men (18 -30 years). 32 young men received 600mg/day of Tongkat Ali or placebo for two weeks.
Conclusions:
Tongkat Ali supplementation increases testosterone and free testosterone levels in young men due to direct stimulation of the adrenal gland in the HPA axis and to a lesser extent the HPG axis. The TA supplement (for two weeks) was found to be acceptable, with no adverse effects on young males even at higher doses (600mg/day).
A randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of Physta® TA in improving testosterone levels and quality of life in ageing male subjects. The study enrolled 105 participants, with 35 in each group (Physta® 100 mg, Physta® 200 mg, and placebo).
Conclusions:
The study concludes that supplementation with Physta® Tongkat Ali at doses of 100 mg and 200 mg can significantly improve total testosterone levels in aged male subjects with low testosterone levels, resulting in enhanced quality of life scores and reduced symptoms of aging and fatigue. No adverse events occurred directly as a result of Tongkat Ali supplementation.
Study on 320 patients suffering from late-onset hypogonadism (LOH), where 76 out of 320 patients with late-onset hypogonadism were given 200 mg of Physta® standardised water-soluble extract of TA for 1 month, to determine whether standardised water-soluble extract of Tongkat ali significantly improved the Ageing Males’ Symptoms (AMS) score and serum testosterone concentration
Conclusions:
The results suggest that Tongkat Ali is a suitable herbal supplement in overcoming symptoms of hypogonadism with improvement in testosterone levels.
A randomized, double-blind, placebo-controlled study was conducted on 109 men (30 – 55) to investigate the clinical evidence of TA as a remedy for decreased male libido. The study involved treatment with 300mg of water extract of TA (Physta®) or a placebo for 12 weeks.
Conclusions:
The study found significant improvements in libido, erectile function, and physical functioning with a daily dose of 300mg of TA (Physta®) extract for three months. The extract was also found to have a strong impact on seminal fluid parameters such as semen volume and sperm motility, as well as fat mass reduction for overweight subjects.
A randomized, double-blind, placebo-controlled clinical study investigating the effects of Physta® Tongkat Ali (also known as LJ100 in the USA) with Bergamot Orange on 97 obese men for 112 days.
Conclusions:
The study findings suggested that a 400mg daily dose of Physta Tongkat Ali and Citrus Bergamia was effective in reducing body weight in obese patients after 112 days.
Author: Hancke et. al, 2021
A randomized, double-blind, placebo-controlled study investigating the effects of Physta® Tongkat Ali extract on men’s testosterone levels and overall health. 20 test subjects (35 – 58 years) were tested on 200 mg, 400 mg and 600 mg/day of Physta® Tongkat Ali for 3 weeks.
Conclusions:
The study confirmed the effect of Tongkat Ali on testosterone, which increased after 3 weeks, as well as overall men’s health, including lower blood glucose for diabetic volunteers, and increased overall sexual health scores.
Author: Tambi et al., 2005
A randomized, double-blind, placebo-controlled study investigating the effects of Physta® Tongkat Ali extract on male athletes at mountain biking events. 30 test male subjects were tested on 100mg daily dose of Physta® Tongkat Ali before exercise.
Conclusions:
Overall, the study confirmed the anabolic benefits of Tongkat Ali in improving performance and reducing fatigue during exercise, as well as increasing testosterone levels and reducing cortisol levels.
Author: Talbot et al., 2007
An open-label study investigating the effects of Physta® Tongkat Ali extract at 200mg / day over on men’s (31 – 52 years) to investigate total and free testosterone, energy, psychological wellbeing and libido levels
Conclusions:
Overall, the study confirmed the benefit of Tongkat Ali in men for improving total and free testosterone levels, DHEA, energy, psychological well-being and libido levels.
Author: Tambi, 2009
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 200mg Physta® Tongkat Ali and 100mg P.minus /day for 12 weeks on 26 (45 – 60) men with mild ED.
Conclusions:
The study confirmed the benefit of Tongkat Ali in men for improving scores related to sexual intercourse attempts, erection hardness, sexual health inventory, and aging male symptoms
A randomized, double-blind, placebo-controlled, study investigating the effects of 50mg Physta® /day for 5 weeks on 13 (27 – 30) healthy men.
Conclusions:
Overall, the study verified the benefit of Tongkat Ali in men for improving muscle circumference and increase in strength with strength training after 5 weeks.
Author: Hamzah et al., 2002
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 100mg Physta® Tongkat Ali per day for 5 weeks on body composition, muscle strength, and size in 14 healthy men.
Conclusions:
The findings suggest that Tongkat Ali supplementation enhances fat-free mass, reduces body fat, and improves muscle strength and size, potentially offering ergogenic effects.
Author: Hamzah et al., 2003
An open-label study investigating the effects of Physta® Tongkat Ali on 75 men with idiopathic infertility with 200mg daily dosage for 3 months.
Conclusions:
Overall, the study confirmed the benefit of Tongkat Ali in men for reducing idiopathic infertility by improving sperm concentration, motility, and morphology.
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 300mg Physta® Tongkat Ali per day for 12 weeks on 26 men (30 – 55) on men’s health, strength, and fertility.
Conclusions:
Overall, the study confirmed the benefit of Tongkat Ali in men for reducing idiopathic infertility by improving sperm concentration, motility, and morphology.
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 300mg Physta® /day for 12 weeks on 40 men (30 – 55) on whether improvements in strength and doping effects were recorded with supplementation.
Conclusions:
Overall, the study confirmed the benefit of Tongkat Ali in men for improving muscular strength in men. Meanwhile, no doping-like effects were observed over the supplementation period.
Author: George et al., 2013
A double-blind, placebo-controlled, and crossover study investigating the effects of 400mg Physta® Tongkat Ali (6 weeks + 3 weeks washout + 6 weeks crossover) on 13 men (24 – 34) on whether doping-like effects were recorded with supplementation.
Conclusions:
The study reported that no changes in both liver and renal functions after Tongkat Ali supplementation, with no doping-like effects recorded after 6 weeks of using Tongkat Ali. This confirms Tongkat Ali doesn’t affect the T:E doping ratio.
Author: Chen et al., 2014
A randomized, double-blind, placebo-controlled, and parallel study investigating the effects of 200 mg SLP+® and 50 mg Physta® Tongkat Ali per day for 24 weeks on 119 pre-menopausal and menopausal women (40 – 55 years).
Conclusions:
Tongkat Ali supplementation reduces hot flushes by 65%, improves joint pain symptoms by 68% and improvements in hormone and lipid profiles (cholesterol & triglycerides) in healthy peri-menopausal and menopausal women.
A randomized, double-blind, placebo-controlled study investigating the effects of Physta® Tongkat Ali on physical strength and physical functions of 31 women (age 45 – 59 years) based on a daily dose of 100mg for 14 weeks.
Conclusions:
Overall, the study confirmed that Tongkat Ali supplementation counteracts age-related decline in physical functions. Tongkat Ali showed significant improvement in physical strength, balance and flexibility in women who are exposed to regular exercises.
Author: Md. Yusof, 2009
WARNING
Please refer to Examine.com and Medical News Today for other Tongkat Ali studies and clinical studies which are not covered in this article.
Pregnant and breastfeeding woman and children below 18 years of age should not be taking Tongkat Ali. Tongkat Ali is a dietary supplement and we recommend you consult your medical professionals or doctors for advice before consuming Tongkat Ali.
Tongkat Ali Clinical Trials on Mood Parameter: Clinicaltrials.gov (Ref: NCT05347329)
Meta-Analysis on Clinical Efficacy of Tongkat Ali: American Botanical Council (Ref: HC# 111564-544)
Ask our experts on Tongkat Ali studies, clinical trials and research studies. Expand your knowledge on Tongkat Ali.
Naressa Khan contributes regularly on AKARALI and is part of the global Tongkat Ali research team. As a writer and journalist, Naressa specializes in nutrition, health supplements, and natural wellness. With this approach always in mind, she explores fact-based and scientific evidence of topics related to health, herbs and natural wellness.
Our articles are third party reviewed by our panel of experts and medical advisors to ensure the facts are accurate and credible. These are validated against multiple source references which include but not limited to research studies, peer-reviewed journals, pre-clinical studies, clinical tests and other credible publications.
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